Stevens Johnson Syndrome
Medicine Reaction / Side Effect
At Stevens Johnson Syndrome, we are dedicated to sharing the understanding and treatment of this rare and life-threatening skin condition. We share research to identify the underlying causes, develop effective therapies, and improve patient outcomes. With a focus on medication-induced cases, we work tirelessly to prevent and mitigate the devastating effects of this syndrome.
Jha N, Alexander E, Kanish B, Badyal DK. A Study of Cutaneous Adverse Drug Reactions in a Tertiary Care Center in Punjab. Indian Dermatol Online J. 2018 Sep-Oct;9(5):299-303. [PMC free article] [PubMed]
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Auyeung J, Lee M. Successful Treatment of Stevens-Johnson Syndrome with Cyclosporine and Corticosteroid. Can J Hosp Pharm. 2018 Jul-Aug;71(4):272-275. [PMC free article] [PubMed]
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Iyer G, Srinivasan B, Agarwal S, Ravindran R, Rishi E, Rishi P, Krishnamoorthy S. Boston Type 2 keratoprosthesis- mid term outcomes from a tertiary eye care centre in India. Ocul Surf. 2019 Jan;17(1):50-54. [PubMed]
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Frey N, Bodmer M, Bircher A, Jick SS, Meier CR, Spoendlin J. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Association with Commonly Prescribed Drugs in Outpatient Care Other than Anti-Epileptic Drugs and Antibiotics: A Population-Based Case-Control Study. Drug Saf. 2019 Jan;42(1):55-66. [PubMed]
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Sato S, Kanbe T, Tamaki Z, Furuichi M, Uejima Y, Suganuma E, Takano T, Kawano Y. Clinical features of Stevens-Johnson syndrome and toxic epidermal necrolysis. Pediatr Int. 2018 Aug;60(8):697-702. [PubMed]
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Yang SC, Hu S, Zhang SZ, Huang JW, Zhang J, Ji C, Cheng B. Corrigendum to "The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China". J Immunol Res. 2018;2018:4154507. [PMC free article] [PubMed]
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Velasco-Tirado V, Alonso-Sardón M, Cosano-Quero A, Romero-Alegría Á, Sánchez-Los Arcos L, López-Bernus A, Pardo-Lledías J, Belhassen-García M. Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015). PLoS One. 2018;13(6):e0198582. [PMC free article] [PubMed]
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Safiri S, Ashrafi-Asgarabad A. The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs: Comment on data sparsity. Epilepsia. 2018 May;59(5):1083-1084. [PubMed]
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Tangamornsuksan W, Lohitnavy M. Association Between HLA-B*1301 and Dapsone-Induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-analysis. JAMA Dermatol. 2018 Apr 01;154(4):441-446. [PMC free article] [PubMed]
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Richard EB, Hamer D, Musso MW, Short T, O'Neal HR. Variability in Management of Patients With SJS/TEN: A Survey of Burn Unit Directors. J Burn Care Res. 2018 Jun 13;39(4):585-592. [PubMed]
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Bettuzzi T, Penso L, de Prost N, Hemery F, Hua C, Colin A, Mekontso-Dessap A, Fardet L, Chosidow O, Wolkenstein P, Sbidian E, Ingen-Housz-Oro S. Trends in mortality rates for Stevens-Johnson syndrome and toxic epidermal necrolysis: experience of a single centre in France between 1997 and 2017. Br J Dermatol. 2020 Jan;182(1):247-248. [PubMed]
P Puri, ZM Aslam, FNU Komal, FNU Prachi, P Sardana… - Cureus, 2023 - ncbi.nlm.nih.gov… Stevens-Johnson syndrome and toxic epidermal necrolysis overlap is … reaction that can
lead to death if not treated aggressively and adequately. Drug-induced hypersensitivity reactions …Save Cite Cited by 1 Related articles All 7 versions[HTML] nih.gov
M Sandhu, KC Binod, J Bhandari, HS Gambhir… - Cureus, 2023 - ncbi.nlm.nih.gov… Stevens-Johnson syndrome (SJS) occurring in a 75-year-old female 14 days after receiving
the first dose of pembrolizumab therapy to treat … presents as an adverse drug reaction [1,2]. …Save Cite Cited by 4 Related articles All 8 versions
Can A Drug Cause Stevens Johnson Syndrome?
Without Warning
Severe Skin Reactions: SJS causes extensive skin blistering and peeling, which can lead to significant pain and discomfort.
Infections: The loss of skin can make you more susceptible to infections, including sepsis, which is a life-threatening condition.
Organ Damage: SJS can affect internal organs, leading to complications such as pneumon
Severe Skin Reactions: SJS causes extensive skin blistering and peeling, which can lead to significant pain and discomfort.
Infections: The loss of skin can make you more susceptible to infections, including sepsis, which is a life-threatening condition.
Organ Damage: SJS can affect internal organs, leading to complications such as pneumonia, liver damage, and kidney failure.
Eye Problems: SJS can cause severe eye issues, including conjunctivitis, corneal ulcers, and even blindness.
Respiratory Issues: The condition can lead to respiratory complications, especially if the mucous membranes of the respiratory tract are affected.
Long-term Skin Problems: After recovery, you might experience long-term skin issues, such as scarring and changes in skin pigmentation.
Mortality: SJS has a significant mortality rate, especially if it progresses to Toxic Epidermal Necrolysis (TEN), which is a more severe form of the condition.
It's crucial to seek immediate medical attention if you suspect you have SJS, as early intervention can help manage symptoms and reduce the risk of complications.
Recovery from stevens Johnson Syndrome
Stevens-Johnson Syndrome (SJS):
Recovering from Stevens-Johnson Syndrome (SJS) can be a lengthy and challenging process. Here are some key aspects of the recovery process:
- Hospitalization: Most patients with SJS require hospitalization, often in an intensive care unit or burn unit, to manage the condition and prevent complications.
- Stopping the Trigger: The first step in treatment is to stop taking any medications that may have caused the reaction.
- Supportive Care: This includes fluid replacement, wound care, and pain management. Patients may receive fluids and nutrients through a nasogastric tube, and cool, wet compresses can help soothe blisters.
- Medications: Pain medications, topical steroids, antibiotics, and other systemic medications like corticosteroids and intravenous immune globulin may be used to control symptoms and prevent infections.
- Eye Care: Since SJS can affect the eyes, care from an ophthalmologist is often necessary to manage eye-related complications.
- Long-Term Recovery: Full recovery can take several weeks to several months, depending on the severity of the condition. Skin can regrow within a few weeks, but some long-term effects, such as skin dryness, itching, and changes in skin color, may persist.
- Follow-Up Care: Regular follow-up appointments with healthcare providers are essential to monitor recovery and manage any ongoing symptoms or complications.
Recovering from SJS requires patience and comprehensive medical care